The Influence of Laboratory Scanner versus Intra-Oral Scanner on Determining Axes and Distances between Three Implants in a Straight Line by Using Two Different Intraoral Scan Bodies: A Pilot In Vitro Study.

BACKGROUND: The purpose of this in vitro study was to compare the inter-implant distance, inter-implant axis, and intra-implant axis of three implants in a straight line by using a laboratory scanner (LBS) versus an intra-oral scanner (IOS) with two different intra-oral scan bodies (ISBs). METHODS: A 3D model was printed with internal hex implant analogs of three implants in positions 15#, 16#, and 17#. Two standard intra-oral scan bodies (ISBs) were used: MIS ISB (two-piece titanium) and Zirkonzhan ISB (two-piece titanium). Both ISBs were scanned using 7 Series dental wings (LBS) and 30 times using Primescan (IOS). For each scan, a stereolithography (STL) file was created and a comparison between all the scans was performed through superimposition of the STL files by using 3D analysis software (PolyWorks® 2020; InnovMetric, Québec, QC, Canada). A Kolmogorov-Smirnov test was performed followed by a Mann-Whitney test (p < 0.05). RESULTS: The change in inter-implant distance for the MIS ISB was significantly lower compared to the ZZ (p < 0.05). The change in intra-implant angle was significantly lower for the ZZ ISB compared to MIS (p < 0.05). The changes in inter-implant angle between the mesial and middle and between the middle and distal were significantly lower for MIS compared to ZZ in contrast to mesial to distal, which was significantly higher (p < 0.05). CONCLUSIONS: Both ISBs showed differences in all the parameters between the LBS and the IOS. The geometry of the scan abutment had an impact on the inter-implant distance as the changes in the inter-implant distance were significantly lower for the MIS ISB. The changes in the intra-implant angle were significantly lower for the ZZ ISB. There is a need for further research examining the influence of geometry, material, and scan abutment parts on the trueness.

"Picking up the pieces": Patients' retrospective reflections of rupture resolution episodes during treatment.

Objective: Although theorists and researchers have stressed the importance of rupture resolution episodes for successful treatment process and outcome, little is known about patients' retrospective reflections about rupture resolution. Aim: The overarching goal of the present study was to use a mixed-method approach to examine patients' retrospective reflections on the frequency, types, and consequences of rupture resolution episodes and the association between rupture resolution episodes and patients' attachment orientation and treatment outcome. Method: Thirty-eight patients diagnosed with major depressive disorder (MDD) were interviewed, on average three years after termination, about their experiences of ruptures in short-term dynamic psychotherapy. Results: Thirty patients reported having experienced at least one rupture, with patients who showed less improvement in depressive symptoms more likely to report having had a rupture. Ruptures were judged as having been successfully resolved for 13 of these patients; suggesting that patients with a high level of attachment anxiety were less likely to be judged as having had a successful resolution. Patients whose ruptures were successfully resolved with the therapist's help reported better treatment process and outcome than patients whose ruptures were not successfully resolved. Conclusion: Results highlight the importance of hearing patients' perspectives on ruptures, rupture resolution, and treatment outcome.

Elevated thrombin generation levels in the left atrial appendage in patients with atrial fibrillation.

Background: Atrial Fibrillation (AF) is the most common sustained tachi-arrhythmia. Thrombus formation in the left atrial appendage (LAA) increases the risk of stroke and systemic embolism in patients with AF. Objectives: The aim of this study was to compare thrombin generation in the LAA to the LA among patients with AF. Methods: A cross-sectional study of consecutive patients with AF undergoing pulmonary veins catheter ablation. Blood samples from the femoral vein (FV), right atrium (RA), left atrium (LA), and LAA were collected during the catheter ablation procedures. Thrombin generation was assessed by a Calibrated Automated Thrombogram. The LAA-calibrated automated thrombogram parameters were compared with the RA, LA, and FV. Results: A total of 47 consecutive patients were enrolled in the study. The endogenous thrombin potential and peak height were significantly higher in the LAA compared with the LA, the mean differences and 95% CI between the LA and LAA were -378.9 (-680.5, -77.2) (nM∗min) and -66.7 (-119.6, -13.8) (nM) in the endogenous thrombin potential and peak height respectively. Conclusion: In patients with AF undergoing catheter ablation, the LAA demonstrated increased thrombin generation compared with the LA. This finding might contribute to the understanding of why the LAA is more predisposed to thrombus formation than the LA. Clinical Trials Registration: NCT03795883.

Entomopathogenic nematodes and their symbiotic bacteria: from genes to field uses.

The term "microbial control" has been used to describe the use of microbial pathogens (bacteria, viruses, or fungi) or entomopathogenic nematodes (EPNs) to control various insect pest populations. EPNs are among the best biocontrol agents, and major developments in their use have occurred in recent decades, with many surveys having been conducted all over the world to identify EPNs that may have potential in the management of insect pests. For nematodes, the term "entomopathogenic" means "causing disease to insects" and is mainly used in reference to the bacterial symbionts of Steinernema and Heterorhabditis (Xenorhabdus and Photorhabdus, respectively), which cause EPN infectivity. A compendium of our multiannual experiences on EPN surveys and on their collection, identification, characterization, and use in agro-forestry ecosystems is presented here to testify and demonstrate once again that biological control with EPNs is possible and offers many advantages over chemicals, such as end-user safety, minimal damage to natural enemies, and lack of environmental pollution, which are essential conditions for an advanced IPM strategy.

The Association Between Opioid Use and Opioid Type and the Clinical Course and Outcomes of Acute Pancreatitis.

OBJECTIVES: Basic science studies suggest that opioids aggravate disease severity and outcomes in acute pancreatitis. We sought to determine the association of opioid use and opioid type with the clinical course and outcome of acute pancreatitis. METHODS: In this retrospective single-center observational study, we included all adult patients admitted with acute pancreatitis between 2008 and 2021. Patients were classified into 3 groups based on analgesia type: morphine, noonmorphine opioid, and nonopioid. RESULTS: We included 2308 patients. Of the patients, 343 (14.9%) were treated with morphine, 733 (31.8%) were treated with nonmorphine opioids, and 1232 (53.4%) patients were in the nonopioid group. The incidence of 30-day mortality did not differ significantly between study groups: 3.9%, 2.9%, and 4.4% in the nonopioid, nonmorphine-opioid, and morphine groups, respectively ( P = 0.366).In multivariate analysis, the composite end point consisting of 30-day mortality, invasive ventilation, emergent abdominal surgery, and need for vasopressors was significantly more likely to occur in the morphine group than in the nonopioid group (adjusted odds ratio, 1.69; 95% confidence interval, 1.1-2.598; P = 0.01). CONCLUSIONS: Mortality among acute pancreatitis patients did not differ significantly between patients receiving morphine, nonmorphine opioids, and nonopioids. However, morphine treatment was associated with higher rates of some serious adverse events.

Bioexploration and Phylogenetic Placement of Entomopathogenic Fungi of the Genus Beauveria in Soils of Lebanon Cedar Forests.

The cedar forests of Lebanon have been threatened by the outbreak caused by climate change of a web-spinning sawfly, Cephalcia tannourinensis (Hymenoptera: Pamphiliidae), which negatively impacted the survival of one of the oldest tree species on earth. In this study, we investigated the occurrence of naturally soil-inhabiting entomopathogenic fungi for their role in containing the massive outbreak of this insect. We used a combination of fungal bioexploration methods, including insect bait and selective media. Morphological features and multilocus phylogeny-based on Sanger sequencing of the transcripts encoding the translation elongation factor 1-alpha (TEF-α), RNA polymerase II second largest subunit (RBP2), and the nuclear intergenic region (Bloc) were used for species identification. The occurrence rate of entomopathogenic fungi (EPF) varied with location, soil structure, forest structure, and isolation method. From 15 soil samples positive for fungal occurrence, a total of 249 isolates was obtained from all locations using different isolation methods. The phylogenetic analysis confirmed the existence of two novel indigenous species: Beauveria tannourinensis sp. nov. and Beauveria ehdenensis sp. nov. In conclusion, the present survey was successful (1) in optimizing the isolation methods for EPF, (2) investigating the natural occurrence of Beauveria spp. in outbreak areas of C. tannourinensis, and (3) in characterizing the presence of new Beauveria species in Lebanese cedar forest soil.

Hydroxychloroquine and Coronavirus Disease 2019: A Systematic Review of a Scientific Failure.

INTRODUCTION: Hydroxychloroquine (HCQ) emerged early in the course of the coronavirus disease 2019 (COVID-19) pandemic as a possible drug with potential therapeutic and prophylactic benefits. It was quickly adopted in China, Europe, and the USA. We systematically reviewed the existing clinical evidence of HCQ use for the prevention and treatment of COVID-19. METHODS: We screened for clinical studies describing HCQ administration to treat or prevent COVID-19 in PubMed. We included randomized controlled trials (RCTs), non-randomized comparative cohorts, and case series studies that had all undergone peer review. RESULTS: A total of 623 studies were screened; 17 studies evaluating HCQ treatment were included. A total of 13 were observational studies, and 4 were RCTs. In terms of effect on mortality rates, observational studies provided conflicting results. As a whole, RCTs, including one large British RCT that has not yet been published, showed no significant effect of HCQ on mortality rates, clinical cure, and virologic response. The use of HCQ as a post-exposure prophylactic agent was found to be ineffective in one RCT. CONCLUSION: There is no evidence supporting HCQ for prophylaxis or treatment of COVID-19. Many observational trials were methodologically flawed. Scientific efforts have been disappointingly fragmented, and well-conducted trials have only recently been completed, more than 7 months and 600,000 deaths into the pandemic.

No silêncio de seus arquivos, as misericórdias nos falam / In the silence of their archives, the houses of mercy talk to us

Faz uma abordagem sobre o projeto que gerou o 'Guia dos arquivos das Santas Casas de Misericórdia do Brasil'. Falar sobre o projeto significa exercitar uma reflexão e um diálogo, tanto no que diz respeito ao significado de um projeto dessa natureza e ao seu desenrolar quanto ao potencial desses arquivos na busca de compreensão de trajetórias vividas em âmbitos diversos, por meio das quais se forjaram dimensões da experiência social, de áreas profissionais e de serviços públicos, dentre as quais as referidas à Saúde.

No silêncio de seus arquivos, as misericódias nos falam / In the silence of their archives, the houses of mercy talk to us

Faz uma abordagem sobre o projeto que gerou o 'Guia dos arquivos das Santas Casas de Misericórdia do Brasil'. Falar sobre o projeto significa exercitar uma reflexão e um diálogo, tanto no que diz respeito ao significado de um projeto dessa natureza e ao seu desenrolar quanto ao potencial desses arquivos na busca de compreensão de trajetórias vividas em âmbitos diversos, por meio das quais se forjaram dimensões da experiência social, de áreas profissionais e de serviços públicos, dentre as quais as referidas à Saúde. (AU)